Oocyte donation in menopausal women

Area of Science:

• Reproductive Medicine
• Infertility Treatment
• Assisted Reproductive Technology

Background:

• Advanced maternal age (≥40 years) presents significant challenges in achieving successful pregnancies.
• Oocyte donation offers a viable solution for women with diminished ovarian reserve or advanced reproductive age.
• Assisted reproductive technologies (ART) are crucial for managing infertility in older women.

Purpose of the Study:

• To evaluate the efficacy of oocyte donation and in-vitro fertilization (IVF) in women of advanced reproductive age.
• To identify factors influencing pregnancy outcomes, specifically endometrial thickness, in oocyte donation cycles.
• To assess the safety and success rates of oocyte donation in a cohort of older women.

Main Methods:

• Retrospective analysis of 82 women undergoing oocyte donation with IVF and embryo transfer.
• Patient demographics, including age (average 48 years) and follicle-stimulating hormone (FSH) levels, were recorded.
• Endometrial thickness was measured using vaginal ultrasound prior to embryo transfer.

Main Results:

• 32 clinical pregnancies were achieved out of 82 cycles.
• Pregnancy outcomes included 21 term deliveries (26 newborns), 3 ongoing pregnancies, and 8 pregnancy losses.
• The highest implantation rates were observed when endometrial thickness was between 9-12 mm.

Conclusions:

• Oocyte donation is an effective treatment for achieving pregnancy in women aged 40 and above.
• Endometrial thickness is a critical factor for successful embryo implantation in oocyte donation cycles.
• Careful monitoring of endometrial receptivity is essential for optimizing IVF outcomes in this patient population.