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Malignant transformation of osteoblastoma: study using image analysis microdensitometry
J Grace1, S McCarthy, R Stankovic
1Department of Anatomical Pathology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.
Journal of Clinical Pathology
|November 1, 1993
Summary
Nuclear DNA analysis revealed changes indicating malignancy in an osteoblastoma case over five months. This DNA microdensitometry detected aneuploidy before morphological signs of cancer appeared.
Area of Science:
- Oncology
- Genetics
- Pathology
Background:
- Osteoblastoma is a rare benign bone tumor.
- Malignant transformation of osteoblastoma to osteosarcoma can occur.
- Monitoring tumor progression requires accurate diagnostic tools.