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Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
Published on: May 6, 2019
The antitumor immune response as a problem of self-nonself discrimination: implications for immunotherapy
P Golumbek1, H Levitsky, L Jaffee
1Department of Oncology, Medicine and Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205-2196.
Abstract:
Much evidence now exists that tumors possess specific antigens recognizable by T cells. The goal of immunotherapy is to break tolerance to these antigens while preserving self-tolerance. Recently, newer approaches have been developed in animal systems that modify tumor cells genetically so that they express new antigens or secrete certain cytokines. Engineering tumor cells to secrete cytokines in a paracrine fashion can induce powerful local cytokine effects which, in addition to inducing local inflammation, can alter the presentation of tumor antigens or the activation of tumor-antigen-specific T lymphocytes, resulting in systemic antitumor immunity.
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