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Gingival crevicular fluid IL-8: correlation with local IL-1 beta levels and patient estrogen status
J B Payne1, R A Reinhardt, M P Masada
1Department of Surgical Specialties, University of Nebraska Medical Center, College of Dentistry, Lincoln 68583-0740.
Journal of Periodontal Research
|November 1, 1993
Abstract:
Gingival crevicular fluid (GCF) IL-8 and IL-1 beta levels were determined by sandwich enzyme-linked immunosorbent assays. Associations between IL-8 and IL-1 beta GCF levels, and between these cytokines and patient estrogen status were evaluated. IL-8 and IL-1 beta were detected more frequently and in higher amounts/30 s GCF sample in estrogen-deficient patients than in estrogen-sufficient patients. IL-8 and IL-1 beta GCF levels were significantly correlated. These findings suggest that GCF IL-8 levels are associated with patient estrogen status and local IL-1 beta concentrations.