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Hemorrhagic cystitis associated with herpes simplex virus

C McClanahan1, M M Grimes, E Callaghan

  • 1Department of Pathology, Medical College of Virginia, Virginia Commonwealth University, Richmond.

The Journal of Urology
|January 1, 1994
PubMed
Summary

Herpes simplex virus (HSV) can cause hemorrhagic cystitis, a rare bladder inflammation. This case highlights HSV as a potential cause even in immunocompetent individuals without widespread infection.

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Area of Science:

  • Urology
  • Virology
  • Pathology

Background:

  • Hemorrhagic cystitis is a serious bladder condition with various potential causes.
  • Viral infections are recognized etiologies of hemorrhagic cystitis.
  • Herpes simplex virus (HSV) is a common virus but rarely implicated in bladder infections.

Observation:

  • A 45-year-old male presented with symptoms of hemorrhagic cystitis.
  • Diagnostic investigations including biopsy, immunohistochemistry, and in situ hybridization confirmed a bladder infection.
  • The patient exhibited no signs of immunosuppression or disseminated HSV infection.

Findings:

  • The bladder biopsy definitively identified herpes simplex virus as the causative agent of hemorrhagic cystitis.
  • This diagnosis was supported by specific viral detection techniques.

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  • This represents one of the few documented cases of HSV-induced hemorrhagic cystitis.

    • Implications:

    • This case expands the known clinical spectrum of herpes simplex virus infections.
    • It underscores the importance of considering viral etiologies, specifically HSV, in cases of hemorrhagic cystitis, even in immunocompetent patients.
    • Further research may be warranted to understand the pathogenesis and prevalence of HSV cystitis.