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[Effect of cefditoren pivoxil on carnitine metabolism in pediatric patients]
1Department of Pediatrics, School of Medicine, Teikyo University.
Insights
Cefditoren pivoxil (CDTR-PI) treatment in pediatric infections altered carnitine metabolism, increasing urinary excretion and decreasing serum free carnitine. Levels normalized after drug discontinuation, with no observed carnitine-related side effects.
Area of Science:
- Biochemistry
- Pediatric Pharmacology
- Infectious Diseases
Abstract:
Carnitine metabolism was studied in 16 pediatric patients with various infections under the treatment with cefditoren pivoxil (CDTR-PI) in granular form. Pivalic acid released from pivaloyloxymethyl ester of the drug was metabolized to pivaloylcarnitine. As results, an increase in urinary carnitine excretion (predominantly as pivaloylcarnitine) and, a decrease in free carnitine concentration and a high acyl/free carnitine ratio in serum (plasma) were observed during the treatment. When the dosing was terminated, pivaloylcarnitine in plasma and then in urine disappeared, and the concentration of free carnitine, acyl/free carnitine ratio returned to the normal range. No carnitine-related side effects were observed throughout the study.