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[Gonadotropin receptor system and its signal transduction pathway]
M Takami1, H Sakamoto, K Satoh
1Department of Obstetrics and Gynecology, Nihon University School of Medicine.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|October 1, 1993
Abstract:
Recent advances in genetic studies have elucidated structure of gonadotropin receptors. This transmembrane receptor contains seven transmembrane domains and induces multiple biological changes in granulosa/theca cells resulting in follicular maturation in women. The signal transduction involves G protein mediated systems, cAMP mediated systems and phospholipase C systems. This paper reviews recent advances in gonadotropin receptor system and its signal transduction pathway.