[Histidine-rich glycoprotein in diabetics]

Histidine-rich glycoprotein (HRGP) has been believed to have anti-fibrinolytic activity through its binding to plasminogen. Diabetic complications such as retinopathy or nephropathy are considered to be related to impaired coagulation-fibrinolysis system. Therefore, we studied the serum levels of HRGP in diabetics. There were no significant alterations of serum HRGP levels in comparison with normal controls, nor was there a mutual relation between HRGP levels and HbA1 values. Moreover, the molecular weight of HRGP was not deviated from control. These results suggest that HRGP might not have critical role on fibrinolytic system in diabetics.