Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ifosfamide causes a diazepam-sensitive encephalopathy

N A Simonian1, F G Gilliam, K H Chiappa

  • 1Department of Neurology, Massachusetts General Hospital, Boston 02114.

Neurology
|December 1, 1993
PubMed
Summary

Ifosfamide (IFX) chemotherapy can cause encephalopathy. Intravenous diazepam rapidly improved mental status and EEG in two patients with IFX-induced encephalopathy, suggesting its use.

Related Experiment Videos

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adverse antiepileptic drug effects in new-onset seizures: a case-control study.

Neurology·2011
Same author

Periodic epileptiform discharges in hypoxic encephalopathy: BiPLEDs and GPEDs as a poor prognosis for survival.

Seizure·2009
Same author

Hippocampal 1H-MRSI correlates with severity of depression symptoms in temporal lobe epilepsy.

Neurology·2007
Same author

Epilepsy--success in clinical practice: translating trials to practice.

European journal of neurology·2005
Same author

Evaluating functional MRI procedures for assessing hemispheric language dominance in neurosurgical patients.

Neuroradiology·2005
Same author

Systematic screening allows reduction of adverse antiepileptic drug effects: a randomized trial.

Neurology·2004

Area of Science:

  • Neuroscience
  • Oncology
  • Pharmacology

Background:

  • Ifosfamide (IFX) is a widely used chemotherapeutic agent.
  • IFX administration is associated with a specific neurotoxicity known as IFX-induced encephalopathy.
  • This encephalopathy presents with symptoms like confusion, stupor, and mutism.