[Experimental studies of mechanism and efficiency of sclerosing agents: varicocid and paraffin]

Based on the analyse of publications the authors treated of history and contemporary applications of sclerotherapy. The role, methodics and results of sclerosing therapy among patients with oesophageal varices were also presented. The aim of the study was to examine the mechanism and efficiency of two sclerosing agents which are frequently used in Poland. Examinations were performed on 30 Wistar rats. Their caudal veins were injected with 0.1 ml of Varicocid or paraffin. In the control group the 0.9% solution of NaCl was applicated. Clinical and histologic appraisal were done at 3 weeks postinjection (first or second) of sclerosants. On the base of obtained results the necro-inflammatory properties and considerable higher efficiency of Varicocid were confirmed.