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Adrenal hemorrhage complicating ACTH therapy in Crohn's disease
1Department of Radiology, Babies Hospital, Columbia-Presbyterian Medical Center, New York, NY 10032.
Pediatric Radiology
|January 1, 1993
Insights
High-dose adrenocorticotropic hormone (ACTH) therapy for severe inflammatory bowel disease can cause acute abdomen due to hemorrhagic adrenal glands. This rare complication requires careful monitoring in pediatric patients with Crohn's disease.
Area of Science:
- Endocrinology
- Gastroenterology
- Pediatric Medicine
Background:
- High-dose adrenocorticotropic hormone (ACTH) therapy is a treatment option for severely ill patients with inflammatory bowel disease (IBD).
- Potential adverse effects of ACTH therapy, particularly in pediatric populations, require thorough investigation.
- Crohn's disease is a chronic inflammatory condition affecting the gastrointestinal tract, often requiring intensive treatment regimens.
Abstract:
Huge dose ACTH therapy is used in some severely ill patients with inflammatory bowel disease. We report a teenage girl with Crohn's disease who developed an acute abdomen following ACTH therapy. CT revealed the mass to be a hemorrhagic adrenal gland; the opposite adrenal gland was hypertrophied but without signs of hemorrhage.