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The influence of beta-adrenoceptors on nasal mucosal function
E J Stewart1, M J Cinnamond, P Nicholls
1Eye and Clinic, Royal Victoria Hospital, Belfast, Northern Ireland, United Kingdom.
Rhinology
|September 1, 1993
Summary
Beta-adrenoceptors influence nasal secretion and airflow. Beta-blockers like propranolol increased nasal secretion, while beta-agonists reduced nasal peak expiratory flow, especially during exercise.
Area of Science:
- Pharmacology
- Respiratory Physiology
Background:
- Beta-adrenoceptors play a role in regulating physiological functions.
- Their specific role in human nasal mucosa requires further elucidation.
Purpose of the Study:
- To investigate the function of beta-adrenoceptors in normal human nasal mucosa.
- To assess the effects of agonists and antagonists on nasal secretion and airflow.
Main Methods:
- Two studies involving placebo, beta-agonists (salbutamol, isoprenaline), and beta-antagonists (propranolol, atenolol).
- Measurements included nasal secretion and nasal peak expiratory flow.
- Data collected during rest, exercise, and recovery periods.
Main Results:
- Propranolol transiently increased nasal secretion at rest; exercise increased secretion in all groups.
- Salbutamol and isoprenaline decreased nasal peak expiratory flow at rest and during exercise.
- Atenolol showed no significant effect on nasal peak expiratory flow.
Conclusions:
- Beta-adrenoceptors modulate human nasal secretion and airflow.
- Beta-blockade may increase nasal secretion, while beta-agonists can impair nasal airflow, particularly during exertion.