Related Experiment Videos
Diet-induced thermogenesis in chronic obstructive pulmonary disease
O Hugli1, P Frascarolo, Y Schutz
1Département de Médecine Interne, Centre Hospitalier Universitaire Vaudois, Switzerland.
The American Review of Respiratory Disease
|December 1, 1993
Summary
Patients with chronic obstructive pulmonary disease (COPD) have higher resting energy expenditure but do not show increased diet-induced thermogenesis (DIT), suggesting DIT does not contribute to weight loss in these individuals.
Area of Science:
- Metabolism
- Pulmonary Medicine
- Nutrition Science
Background:
- Chronic obstructive pulmonary disease (COPD) is often associated with increased resting energy expenditure (REE) and malnutrition.
- The role of diet-induced thermogenesis (DIT) in the weight loss observed in COPD patients remains unclear.
Purpose of the Study:
- To investigate whether increased DIT contributes to weight loss in patients with stable COPD.
- To compare DIT between COPD patients and healthy controls.
Main Methods:
- Indirect calorimetry was used to measure resting energy expenditure (REE) before and after a standardized liquid meal.
- Diet-induced thermogenesis (DIT) was assessed over 130 minutes post-meal.
- Eleven stable COPD patients and eleven healthy controls participated.
Main Results:
- COPD patients exhibited significantly higher premeal REE compared to predicted values (109.9% vs 97.5%).
- No significant difference in the percentage increase in REE after the meal (DIT) was observed between COPD patients and controls at 70 minutes (18.8% vs 15.1%) or 130 minutes (16.4% vs 12.4%).
- DIT as a percentage of caloric intake was not significantly different between groups (4.3% vs 3.3%).
Conclusions:
- Patients with stable COPD are hypermetabolic at rest.
- Despite elevated resting energy expenditure, COPD patients do not demonstrate an increased diet-induced thermogenesis.
- Increased DIT does not appear to be a contributing factor to weight loss in stable COPD.