Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Adherens Junctions01:24

Adherens Junctions

Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
The endothelial cells...
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>Ochroconis gallopava</i> bronchitis mimicking haemoptysis in a patient with bronchiectasis.

Respiratory medicine case reports·2017
Same author

[The Ying and Yang of pulmonary microbiota].

Revue medicale suisse·2016
Same author

[The asthma-COPD overlap syndrome].

Revue medicale suisse·2016
Same author

[Chronic obstructive pulmonary disease and its links with cardiovascular risk factors].

Revue medicale suisse·2016
Same author

[Lung abscess: changes in treatment?].

Revue medicale suisse·2016
Same author

[E-cigarette stirs controversies].

Revue medicale suisse·2015

Related Experiment Video

Updated: Jul 2, 2026

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
09:14

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes

Published on: June 13, 2014

Adhesion molecules and cytokine production

J M Dayer1, P Isler, L P Nicod

  • 1Department of Medicine, University Hospital, Geneva, Switzerland.

The American Review of Respiratory Disease
|December 1, 1993
PubMed
Summary

Cell interactions, crucial for immune responses, involve cell surface molecules and soluble factors. Key molecules like integrins and cytokines mediate T-cell, monocyte, and fibroblast communication, influencing inflammation and tissue repair.

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • Cell-to-cell communication is vital for immune responses, utilizing soluble factors and direct contact.
  • Dendritic cells and T cells interact in the lung, producing TNF-alpha and TNF-beta.
  • T-cell and monocyte interactions yield IL-1 beta production.

Purpose of the Study:

  • To elucidate the molecular mechanisms of cell-cell interactions in immune responses.
  • To identify key molecules involved in T-cell, monocyte, and fibroblast communication.
  • To understand the role of cytokines and cell surface molecules in mediating these interactions.

Main Methods:

  • Analysis of cell surface molecule expression.
  • Investigating cytokine production following cell co-culture.

More Related Videos

Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions
07:40

Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions

Published on: June 29, 2016

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation
12:55

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation

Published on: December 9, 2021

Related Experiment Videos

Last Updated: Jul 2, 2026

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
09:14

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes

Published on: June 13, 2014

Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions
07:40

Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions

Published on: June 29, 2016

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation
12:55

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation

Published on: December 9, 2021

  • Utilizing blocking antibodies to inhibit specific molecular interactions.

    • Main Results:

    • LFA-3, CD11c, and integrins (beta 1, beta 2) are efficient in dendritic cell-T cell interactions.
    • CD69, CD2, beta 2 integrins, and a 25- to 35-kD glycoprotein are involved in T cell-monocyte interactions.
    • Monocyte-fibroblast interaction stimulates collagenase and PGE2 production; cell-associated IL-1 and TNF-alpha play roles.

    Conclusions:

    • Cell-cell interactions are mediated by specific molecular players, including cytokines and adhesion molecules.
    • These interactions are critical for immune cell activation, cytokine release, and tissue remodeling.
    • Targeting these interactions offers potential therapeutic strategies for inflammatory conditions.