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[Pseudoxanthoma elasticum and pregnancy]

E Mansat-Krzyzanowska1, P Sagot, N Le Neel

  • 1Clinique Dermatologique, Hôtel Dieu, Nantes.

Annales De Dermatologie Et De Venereologie
|January 1, 1993
PubMed
Summary

Pregnancy in women with pseudoxanthoma elasticum (PXE) poses risks, including transient fetal growth issues. Close monitoring is crucial for these high-risk pregnancies to ensure maternal and fetal well-being.

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Area of Science:

  • Dermatology
  • Obstetrics
  • Vascular Medicine

Background:

  • Pseudoxanthoma elasticum (PXE) is a rare genetic disorder affecting elastic tissues.
  • PXE can manifest with characteristic skin lesions, vascular abnormalities, and ocular findings.
  • Pregnancy in women with PXE presents unique challenges due to potential systemic complications.

Observation:

  • A pregnant woman with PXE experienced typical cutaneous manifestations, lower limb arteritis, and angioid striae.
  • Her pregnancy was complicated by a transient deceleration in fetal growth, which resolved with hospitalization and rest.
  • Delivery via cesarean section at 35 weeks revealed a calcified placenta.

Findings:

  • Post-pregnancy, the patient's skin lesions worsened, while arteritis and ocular involvement remained stable.
  • The case highlights the potential impact of PXE on pregnancy outcomes, including fetal growth and placental health.
  • PXE management during pregnancy requires careful consideration of maternal and fetal risks.

Implications:

  • This case underscores the necessity for meticulous surveillance of pregnancies in women with pseudoxanthoma elasticum.
  • Optimal management strategies for "at-risk" pregnancies involving PXE need further investigation.
  • Early detection and intervention are vital for improving outcomes in PXE-affected pregnancies.

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