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Antibiotics synthesized by posttranslational modification

J N Hansen1

  • 1Department of Chemistry and Biochemistry, University of Maryland, College Park 20742.

Annual Review of Microbiology
|January 1, 1993
PubMed
Summary
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Use of alkaline phosphatase as a reporter polypeptide to study the role of the subtilin leader segment and the SpaT transporter in the posttranslational modifications and secretion of subtilin in Bacillus subtilis 168.

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Antimicrobial peptides, particularly lantibiotics, are modified ribosomally synthesized peptides. Genetic engineering enables the creation of novel lantibiotics with improved antimicrobial properties for future applications.

Area of Science:

  • Microbiology
  • Biochemistry
  • Molecular Genetics

Background:

  • Antimicrobial peptides (AMPs) are produced by diverse organisms and often contain unusual amino acids.
  • While many AMPs are nonribosomally synthesized, this review focuses on ribosomally synthesized peptides undergoing posttranslational modification.
  • Lantibiotics, a class of modified AMPs, include well-known examples like nisin and subtilin, with recent discoveries expanding their diversity.

Purpose of the Study:

  • To review advances in the molecular genetics of lantibiotics.
  • To explore the construction of novel lantibiotics with enhanced properties.
  • To discuss future research trends and potential applications of engineered lantibiotics.

Main Methods:

  • Focus on posttranslational modification of ribosomally synthesized precursor peptides.

Related Experiment Videos

  • Utilizing gene-encoded peptide structures for analog construction via mutagenesis.
  • Leveraging recent molecular genetics insights for engineering lantibiotics.

    • Main Results:

    • Lantibiotic structures are derived from gene-encoded peptides, allowing for analog creation.
    • Advances in molecular genetics facilitate the development of novel lantibiotics.
    • Engineered lantibiotics show potential for enhanced chemical and antimicrobial properties.

    Conclusions:

    • The genetic tractability of lantibiotics allows for the design of improved antimicrobial agents.
    • Future research should focus on harnessing molecular genetics for novel lantibiotic development.
    • Engineered lantibiotics hold promise for various applications in the field of antimicrobial peptides.