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The Loyola University lung transplant experience
J R Doud1, M M McCabe, A Montoya
1Department of Medicine, Loyola University of Chicago, Stritch School of Medicine, Maywood, IL.
Archives of Internal Medicine
|December 27, 1993
Summary
Lung transplantation significantly improves lung function and quality of life for patients with end-stage lung disease. This study shows a threefold improvement in lung capacity post-transplant, with a 73% survival rate.
Area of Science:
- Pulmonology
- Thoracic Surgery
- Transplant Medicine
Background:
- Review of isolated lung transplantation outcomes at Loyola University Medical Center (April 1990 - June 1992).
- 33 lung transplantations performed for end-stage pulmonary disease (30 single lung, 3 bilateral single lung).
- Recipient diagnoses included COPD, alpha 1-antiprotease deficiency, pulmonary fibrosis, and others.
Purpose of the Study:
- To retrospectively review functional indexes before and after lung transplantation in patients with end-stage obstructive airway disease.
- To determine the overall survival rate for isolated lung transplant recipients.
Main Methods:
- Retrospective review of functional indexes (pre- and post-transplantation).
- Analysis of overall survival rates for all isolated lung transplant procedures.
Main Results:
- Successful lung transplantation led to marked improvements in functional capacity.
- Single-lung transplantation for obstructive airway disease showed a threefold increase in 1-second forced expiratory volume (0.49 L to 1.64 L).
- Overall survival rate was 73%, with a 15% 30-day mortality.
Conclusions:
- Isolated lung transplantation significantly enhances functional capacity in patients with end-stage lung disease.
- Lung transplantation can lead to improved quality of life for individuals with severe pulmonary conditions.