Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Trimethyltin encephalopathy

R G Feldman1, R F White, I I Eriator

  • 1Department of Neurology, University Hospital, Boston.

Archives of Neurology
|December 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Measurement of Reactor Antineutrino Oscillation at SNO.

Physical review letters·2025
Same author

Hippocampal volume and vasculature before and after exercise in treatment-resistant schizophrenia.

Schizophrenia research·2018
Same author

Patients with prior vertebral or hip fractures treated with teriparatide in the Direct Assessment of Nonvertebral Fractures in Community Experience (DANCE) observational study.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2015
Same author

Treatment with denosumab reduces secondary fracture risk in women with postmenopausal osteoporosis.

Climacteric : the journal of the International Menopause Society·2015
Same author

Pathogenesis-related proteins in plants and tissues ofNicotiana tabacum transformed byAgrobacterium tumefaciens.

Plant molecular biology·2013
Same author

Biochemical and serological characterization of b-proteins fromNicotiana species.

Plant molecular biology·2013
Same journal

Incorrect Table Entries and Word.

Archives of neurology·2016
Same journal

IDEAL for CCSVI Research-Reply.

Archives of neurology·2013
Same journal

Atlas of Inherited Metabolic Diseases, 3rd ed.

Archives of neurology·2013
Same journal

Error in byline: in heterogeneity of coenzyme q10 deficiency: patient study and literature review.

Archives of neurology·2013
Same journal

This month in archives of neurology.

Archives of neurology·2013
Same journal

About this journal.

Archives of neurology·2013
See all related articles

Acute exposure to trimethyltin (TMT) caused severe neurotoxicity, including delirium and memory loss. Long-term effects persist, with the patient experiencing partial seizures and cognitive dysfunction years later.

Area of Science:

  • Neuroscience
  • Toxicology

Background:

  • Organotin compounds, specifically trimethyltin (TMT), are known neurotoxins.
  • Understanding the acute and chronic effects of TMT exposure is crucial for clinical management and public health.

Observation:

  • A chemistry student experienced acute neurotoxic symptoms, including delirium and memory deficits, 72 hours after TMT vapor exposure.
  • The patient later developed complex partial seizures, requiring long-term anticonvulsant therapy.
  • Persistent cognitive dysfunction, memory defects, and dysphoria were noted up to 4 years post-exposure.

Findings:

  • Trimethyltin was detected in blood and urine samples weeks after exposure, with elevated blood levels persisting for over a month.
  • Serial electroencephalograms revealed persistent epileptogenic potentials in the left temporal lobe.

Related Experiment Videos

  • Neuropsychological testing confirmed lasting memory impairments and cognitive dysfunction.

    • Implications:

    • This case highlights the severe and persistent neurotoxic effects of trimethyltin exposure in humans.
    • The findings confirm TMT's impact on the limbic system, correlating with known histopathological patterns.
    • This study underscores the importance of recognizing and managing TMT poisoning to prevent long-term neurological sequelae.