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Ocular involvement in primary central nervous system lymphoma: an increasing clinical problem?
D E Roos1, P C O'Brien, J L Crompton
1Department of Radiation Oncology, Royal Adelaide Hospital, Australia.
Australasian Radiology
|November 1, 1993
Summary
Primary CNS lymphoma (PCNSL) can relapse in the eye, specifically the vitreous. Regular eye exams are crucial for early detection and management of ocular involvement in PCNSL patients.
Area of Science:
- Neuro-oncology
- Ophthalmology
Background:
- Primary central nervous system lymphoma (PCNSL) is a rare and aggressive malignancy.
- Ocular involvement is a known, though infrequent, complication of PCNSL.
Observation:
- This report details a case of unilateral vitreous relapse in a PCNSL patient after chemotherapy and radiotherapy.
- Ocular involvement, particularly vitreous relapse, can occur even after standard treatment protocols.
Findings:
- Literature review indicates ocular involvement in 15-25% of PCNSL cases.
- Vitreous relapse represents a specific pattern of ocular manifestation in PCNSL.
Implications:
- Routine ophthalmological assessment, including slit lamp examination, is recommended for PCNSL staging at diagnosis.
- Ophthalmological surveillance should continue during and after treatment, especially if relapse is suspected.