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Differential pulse voltammetric determination of 7-hydroxycoumarin in human urine
E Dempsey1, C O'Sullivan, M R Smyth
1School of Chemical Sciences, Dublin City University, Republic of Ireland.
Journal of Pharmaceutical and Biomedical Analysis
|June 1, 1993
Abstract:
The electrochemical behaviour of 7-OH-coumarin at the bare glassy carbon electrode has been studied using differential pulse voltammetry, and based on anodic detection of this metabolite at 0.66 V (vs SCE) using DC amperometry, a method has been developed for the determination of 7-OH-coumarin levels in urine samples, and a pharmacokinetic profile established.