[Effect of suo quan pill for reducing clozapine induced salivation]

40 Schizophrenic inpatients with clozapine induced salivation were divided into two groups randomly. They were treated with Suo Quan pill and a control study of the placebo (neutral pill) for reducing clozapine induced salivation. These cases were also classified by TCM Syndrome Differentiation and laboratory examinations were performed.

There was a significant difference in effect on salivation between the therapeutic group (21 cases) and the controlled group (19 cases), P < 0.01. According to their TCM subtypes two subtypes (Stagnation of Phlegm-Dampness and Yin Deficiency) showed the best results. No correlation between the peripheral clozapine level and salivation was found. No side effect was recorded.