Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Proteolytic activity of Streptococcus mutans (GS-5)

L Rosengren, B Winblad

    Oral Surgery, Oral Medicine, and Oral Pathology
    |December 1, 1976
    PubMed
    Summary

    Streptococcus mutans (GS-5), a cariogenic bacterium, can be induced to produce collagen-degrading enzymes. This finding reveals a potential mechanism for tissue damage associated with this common oral microbe.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Ultrastructural analysis and TUNEL demonstrate motor neuron apoptosis in Werdnig-Hoffmann disease.

    Journal of neuropathology and experimental neurology·2000
    Same author

    Memantine in severe dementia: results of the 9M-Best Study (Benefit and efficacy in severely demented patients during treatment with memantine).

    International journal of geriatric psychiatry·2000
    Same author

    The course of cognitive impairment in preclinical Alzheimer disease: three- and 6-year follow-up of a population-based sample.

    Archives of neurology·2000
    Same author

    Expression of interleukin 1 alpha and beta, and interleukin 1 receptor antagonist mRNA in the rat central nervous system after peripheral administration of lipopolysaccharides.

    Cytokine·2000
    Same author

    Incidence of stroke in relation to cognitive function and dementia in the Kungsholmen Project.

    Neurology·2000
    Same author

    Mild cognitive impairment in the population and physical health: data on 1,435 individuals aged 75 to 95.

    The journals of gerontology. Series A, Biological sciences and medical sciences·2000

    Area of Science:

    • Microbiology
    • Biochemistry
    • Oral Biology

    Background:

    • Cariogenic streptococci, including Streptococcus mutans, are primary agents in dental caries.
    • The proteolytic and collagenolytic potential of oral bacteria is not fully understood.
    • Streptococcus mutans (GS-5) was investigated for its ability to degrade collagen.

    Purpose of the Study:

    • To assess the collagenolytic activity of a specific strain of cariogenic Streptococcus mutans (GS-5).
    • To determine if Streptococcus mutans can be conditioned to produce enzymes that degrade collagen.

    Main Methods:

    • Bacterial cultures of Streptococcus mutans (GS-5) were established from infected rats.
    • Sterile rat tail tendons were exposed to cultured bacterial colonies.
    • Collagenolytic activity was evaluated using scanning electron microscopy and tensile strength testing of collagen fibers.

    Main Results:

    • The study demonstrated that Streptococcus mutans (GS-5) can exhibit significant collagenolytic activity when appropriately conditioned.
    • Scanning electron microscopy revealed structural changes in collagen fibers.
    • Tensile strength tests confirmed the degradation of collagen fibers.

    Conclusions:

    • Streptococcus mutans (GS-5) possesses the capability to degrade collagen.
    • Conditioning Streptococcus mutans can enhance its collagenolytic potential.
    • This proteolytic ability may contribute to the pathogenesis of infections caused by this bacterium.

    Related Experiment Videos