Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Primary hyperparathyroidism in very old patients

P Pfitzenmeyer1, J F Besancenot, B Verges

  • 1Service de Médecine Gériatrique, Centre Hospitalier Régional Universitaire, Dijon, France.

The European Journal of Medicine
|October 1, 1993
PubMed
Summary

Primary hyperparathyroidism (pHPT) significantly impacts very old patients, often presenting with severe neuropsychiatric symptoms. Early detection and surgical intervention can lead to substantial improvements in cognitive function.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Palliative Radiotherapy for Haemostasis in Malignancy: a Systematic Review.

Clinical oncology (Royal College of Radiologists (Great Britain))·2023
Same author

[Colchicine and non-severe ocular inflammation excluding Behcet's disease: 16 cases and literature review].

La Revue de medecine interne·2022
Same author

Dunnigan lipodystrophy syndrome: French National Diagnosis and Care Protocol (PNDS; Protocole National de Diagnostic et de Soins).

Orphanet journal of rare diseases·2022
Same author

Design of a prospective, longitudinal cohort of people living with type 1 diabetes exploring factors associated with the residual cardiovascular risk and other diabetes-related complications: The SFDT1 study.

Diabetes & metabolism·2021
Same author

A Pre-implementation Study of Volumetric Modulated Arc Therapy for Same-day Planning and Treatment of Vertebral Bone Metastases Within a Rapid-access Palliative Radiotherapy Programme.

Clinical oncology (Royal College of Radiologists (Great Britain))·2021
Same author

Whole-exome sequencing identifies the first French MODY 6 family with a new mutation in the NEUROD1 gene.

Diabetes & metabolism·2020

Area of Science:

  • Endocrinology
  • Geriatrics
  • Neurology

Background:

  • Primary hyperparathyroidism (pHPT) is a common endocrine disorder.
  • Its clinical presentation in very elderly individuals (≥75 years) is not well-characterized.
  • Neuropsychiatric manifestations are increasingly recognized in pHPT.

Purpose of the Study:

  • To evaluate the clinical presentation and biological features of pHPT in very old subjects.
  • To highlight the prevalence and severity of neuropsychiatric disorders in this population.
  • To assess the impact of treatment on these symptoms.

Main Methods:

  • Retrospective analysis of 30 patients aged 75 years or older diagnosed with pHPT.
  • Diagnosis confirmed by biological signs, parathyroid imaging, or surgical exploration.

Related Experiment Videos

  • Evaluation of clinical symptoms, serum calcium, parathyroid hormone levels, and treatment outcomes.

    • Main Results:

    • 87% presented with general symptoms, 83% with neuromuscular symptoms, and 73% with neuropsychiatric manifestations.
    • Confusion and depression were common (30% and 27%).
    • Serum calcium was normal in 13% and ≤110 mg/L in 47%; no correlation with mental changes. Parathyroid hormone was abnormal in 93%.
    • Surgery improved all 13 patients; ethanol injection cured 50% of 10 patients.

    Conclusions:

    • pHPT frequently causes significant neuropsychiatric disorders in the very old.
    • These disturbances can improve with surgical treatment.
    • Clinicians should systematically screen elderly patients with cognitive impairment for pHPT.