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[Hereditable characteristics of attenuated live hepatitis A virus H2 strain]
1Virus Research Institute, Zhejiang Academy of Medical Sciences, Huangzhou.
Abstract:
The toxicity of attenuated hepatitis A virus H2 strain was not increased in testing KMB 17 cells of 5 consecutive generations of monkeys at 36 degrees C. After injection of attenuated live hepatitis A virus H2 strain in humans, no abnormality was noted. Serum hepatitis A antigen was positive after 38 children aged 3-9 years were given oral 10(6.5) TCKD50, whereas it was 100% positive in the group of same age after percutaneous vaccination. Noninfection of oral administration is an important hereditable characteristic differentiation from wild strains.
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