Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antibody Targeted Photolysis

M L Yarmush1, W P Thorpe, L Strong

  • 1Department of Chemical and Biochemical Engineering, Rutgers University, Piscataway, NJ 08855-0909.

Critical Reviews in Therapeutic Drug Carrier Systems
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Parallelized Droplet Vitrification Enables Single-Run Vitrification of the Whole Rat Liver Hepatocyte Yield.

bioRxiv : the preprint server for biology·2024
Same author

Electromyographic differences of the gluteus maximus, gluteus medius, biceps femoris, and vastus lateralis between the barbell hip thrust and barbell glute bridge.

Sports biomechanics·2022
Same author

'Out of house' virtual surgical planning for mandible reconstruction after cancer resection: is it oncologically safe?

International journal of oral and maxillofacial surgery·2020
Same author

The Spectrum of Histological Findings in Oral Biopsies

Irish medical journal·2020
Same author

Expanded analysis of secondary germline findings from matched tumor/normal sequencing identifies additional clinically significant mutations.

JCO precision oncology·2019
Same author

Automated end-to-end blood testing at the point-of-care: Integration of robotic phlebotomy with downstream sample processing.

Technology·2018

Antibody Targeted Photolysis (ATPL) uses targeted molecules and light to destroy cells. This review covers ATPL

Area of Science:

  • Immunology
  • Photochemistry
  • Biophysics

Background:

  • Antibody Targeted Photolysis (ATPL) has been explored since 1983.
  • Development of immunoconjugates is key to ATPL efficacy.
  • Understanding photophysical and biological properties is crucial.

Purpose of the Study:

  • To provide a historical review of Antibody Targeted Photolysis (ATPL).
  • To summarize literature on immunoconjugate development and ATPL applications.
  • To present a mathematical model for ATPL-mediated cell killing.

Main Methods:

  • Literature review of ATPL and related photodynamic technologies.
  • Analysis of biological and photophysical properties of immunoconjugates.
  • Development of a mathematical model for cell killing dynamics.

Related Experiment Videos

Main Results:

  • Detailed discussion of immunoconjugate synthesis, toxicity, and biodistribution.
  • Exploration of photosensitizer selection and light delivery strategies.
  • Presentation of a mathematical model with solutions for isolated tumor cells.

Conclusions:

  • ATPL requires careful consideration of multiple factors for successful cell killing.
  • Further research is needed to advance ATPL for clinical therapy and cell biology.
  • Mathematical modeling provides a framework for understanding ATPL dynamics.