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Related Experiment Videos

Peripapillary atrophy in unilateral capsular glaucoma

P Puska1, C Raitta

  • 1Department of Ophthalmology, Helsinki University, Central Hospital, Finland.

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
|November 1, 1993
PubMed
Summary

Peripapillary atrophy in glaucoma is largely an inborn trait, not solely caused by intraocular pressure (IOP). Nerve fiber loss can occur even without significant changes in these optic nerve head tissues.

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Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Optic Nerve Head Imaging

Background:

  • Glaucoma is a leading cause of irreversible blindness.
  • Peripapillary atrophy is a common finding in glaucoma, but its etiology is debated.
  • Understanding the origins of peripapillary atrophy can help differentiate glaucomatous damage from congenital variations.

Purpose of the Study:

  • To compare peripapillary tissues in glaucomatous versus non-glaucomatous eyes within the same individuals.
  • To investigate the relationship between intraocular pressure (IOP), peripapillary atrophy, and optic nerve head damage in glaucoma.

Main Methods:

  • Pairwise comparison of 56 eyes from 28 patients with unilateral early to moderate capsular glaucoma.
  • Analysis included rim area, rim/disc area ratio, cup area, cup volume, disc area, scleral ring area, and peripapillary crescent size.

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  • Correlation analysis between IOP, peripapillary atrophy area, and glaucomatous optic nerve head damage.

    • Main Results:

    • Significant differences were found in rim area, rim/disc area ratio, cup area, and cup volume between glaucomatous and non-glaucomatous eyes.
    • Disc area, scleral ring area, and peripapillary crescent size did not differ significantly.
    • A significant correlation was observed between intraocular pressure (IOP) and the area of peripapillary atrophy in both glaucomatous and non-glaucomatous eyes.
    • The area of peripapillary atrophy significantly correlated with glaucomatous optic nerve head damage.

    Conclusions:

    • The area of peripapillary atrophy appears to be largely an inborn characteristic.
    • Optic nerve fiber loss in glaucoma can occur independently of significant changes in peripapillary tissues.
    • While largely congenital, an intraocular pressure-induced change in the retinal pigment epithelium cannot be entirely excluded.