[Treatment of migraine attacks with sumatriptan]

The serotonin agonist, sumatriptan, is a new, highly promising alternative treatment for migraine that has a vasoconstricting effect on the blood vessels dilated during an attack. In addition, sumatriptan inhibits the neurogen-mediated sterile inflammation associated with migraine. Its effects, pharmacological properties and side effects are discussed and considered in relation to its high price. The subcutaneous form of sumatriptan is indicated for use in attacks accompanied by initial violent vomiting, and the oral form for attacks in which standardised medication elicits either no response or side effects, as also to treat migraine that regularly renders the sufferer unable to work. When attacks are a frequent occurrence, migraine prophylaxis should first be initiated. The significance of cardiovascular side effects is interpreted, and hints provided on instructing the patient in the use of this drug.