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Low-density lipoprotein oxidation in essential hypertension

E Maggi1, E Marchesi, V Ravetta

  • 1Department of Internal Medicine and Medical Therapeutics, University of Pavia, IRCCS Policlinico S. Matteo, Italy.

Journal of Hypertension
|October 1, 1993
PubMed
Summary

Hypertension accelerates atherosclerosis by increasing low-density lipoprotein (LDL) oxidation. This study found LDL from hypertensive patients is more prone to oxidation, suggesting a role in disease progression.

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Area of Science:

  • Cardiovascular Science
  • Oxidative Stress Research

Background:

  • Hypertension is a major risk factor for atherosclerosis.
  • The role of low-density lipoprotein (LDL) oxidation in atherosclerosis is well-established.
  • Enhanced LDL oxidation may contribute to atherosclerosis progression in hypertensive individuals.

Purpose of the Study:

  • To investigate enhanced LDL oxidation in patients with essential hypertension.
  • To determine if LDL oxidation is an independent factor in atherosclerosis development in hypertension.

Main Methods:

  • Assessed LDL susceptibility to oxidation in vitro (conjugated diene generation).
  • Measured plasma anti-oxidized LDL antibodies as an in vivo oxidation marker.
  • Evaluated Vitamin E levels and its protective efficiency within LDL.

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Main Results:

  • Hypertensive patients showed increased LDL susceptibility to in vitro oxidation.
  • Lower Vitamin E levels and impaired protection were observed in hypertensive LDL.
  • Elevated plasma anti-oxidized LDL antibody titers indicated increased in vivo oxidation.
  • These effects were independent of hypercholesterolemia and blood pressure levels.

Conclusions:

  • LDL from hypertensive patients is more susceptible to both in vitro and in vivo oxidation.
  • Enhanced LDL oxidation likely contributes to the accelerated atherosclerosis seen in hypertensive patients.