Is ANP responsible for the hemoconcentration in preeclampsia?
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H Poulsen1, M Sthjernquist, N O Sjöberg
1Department of Obstetrics and Gynecology, University of Lund, General Hospital, Malmö, Sweden.
Abstract:
A hypothesis is presented that high plasma concentration of alpha-human Atrial Natriuretic Peptide (ANP) might be responsible for hemoconcentration of preeclampsia (PE), mediated by increased diuresis and shift of fluid to the interstitium. ANP is known as a peptide regulating blood volume by diuresis and natriuresis, and perhaps through increased permeability in vessels. Moreover ANP is an antagonist to the renin-angiotensin-aldosterone (RAA) system, especially when this system is activated quantitatively as in pregnancy or qualitatively as in PE.
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