Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Proteins regulating Ras and its relatives

M S Boguski1, F McCormick

  • 1National Center for Biotechnology Information, National Library of Medicine, NIH, Bethesda, Maryland 20894.

Nature
|December 16, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Workload for infection prevention and control teams in preventing nosocomial tuberculosis: an underestimated burden.

The Journal of hospital infection·2022
Same author

Ancient DNA, lipid biomarkers and palaeoecological evidence reveals construction and life on early medieval lake settlements.

Scientific reports·2021
Same author

Family-focused practice within a recovery framework: practitioners' qualitative perspectives.

BMC health services research·2017
Same author

In-hospital mortality risk of intertrochanteric hip fractures: a comprehensive review of the US Medicare database from 2005 to 2010.

Musculoskeletal surgery·2017
Same author

ABO-Incompatible Kidney Transplants: Twice as Expensive, Half as Good.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
Same author

A Cost-Benefit Analysis of Government Compensation of Kidney Donors.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
Same journal

Retraction Note: NSD2 targeting reverses plasticity and drug resistance in prostate cancer.

Nature·2026
Same journal

Enhanced B cell priming induces broadly neutralizing HIV-1 apex antibodies.

Nature·2026
Same journal

Vaccination elicits HIV broadly neutralizing antibodies in primates.

Nature·2026
Same journal

Child online safety needs more than social-media bans.

Nature·2026
Same journal

Ebola preparedness must start with ecosystems and before humans show symptoms.

Nature·2026
Same journal

AI tools can speed up thinking, but evidence still comes from the lab bench.

Nature·2026
See all related articles

Ras superfamily GTPases control cell functions by switching between active and inactive states. Researchers are identifying numerous proteins that regulate these GTPases, which are often larger and more complex than their targets.

Area of Science:

  • Molecular and Cellular Biology
  • Biochemistry
  • Cell Signaling

Background:

  • Ras superfamily GTPases are critical regulators of fundamental cellular processes, including growth, differentiation, and motility.
  • Their activity is tightly controlled by cycles of GTP binding and hydrolysis, influencing their cellular localization and function.

Purpose of the Study:

  • To review the known regulators of Ras superfamily GTPases.
  • To highlight the complexity of these regulatory proteins and their interactions within cellular networks.

Main Methods:

  • Literature review of studies on Ras superfamily GTPases and their interacting proteins.
  • Analysis of protein domain structures and functional interactions.

Main Results:

Related Experiment Videos

  • Numerous proteins that modulate GTPase activity, nucleotide exchange, and membrane localization have been identified.
  • Many identified regulators are significantly larger and possess multiple domains compared to the target GTPases.
  • These regulators interact with a complex network of cellular enzymes and structures.

Conclusions:

  • The regulation of Ras superfamily GTPases involves a diverse array of complex proteins.
  • Understanding these intricate regulatory networks is crucial for comprehending cell signaling pathways.
  • Further research into these interactions will elucidate fundamental cellular mechanisms.