Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Progressive Schnyder's corneal dystrophy

H J Ingraham1, H D Perry, E D Donnenfeld

  • 1Department of Ophthalmology, Geisinger Medical Center, Danville, Pennsylvania 17822-2120.

Ophthalmology
|December 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A modified storage protein is synthesized, processed, and degraded in the seeds of transgenic plants.

Plant molecular biology·2013
Same author

Accurate whole-spectrum measurements of intracellular pH and [Na(+)].

Journal of fluorescence·2013
Same author

Clinical outcomes and functional visual performance: comparison of the ReSTOR apodised diffractive intraocular lens to a monofocal control.

The British journal of ophthalmology·2009
Same author

Gene expression analysis in a murine model of allergic asthma reveals overlapping disease and therapy dependent pathways in the lung.

The pharmacogenomics journal·2006
Same author

Critical role for IL-13 in the development of allergen-induced airway hyperreactivity.

Journal of immunology (Baltimore, Md. : 1950)·2001
Same author

Studies of murine schistosomiasis reveal interleukin-13 blockade as a treatment for established and progressive liver fibrosis.

Hepatology (Baltimore, Md.)·2001
Same journal

Avacincaptad Pegol Slows Progressive Ellipsoid Zone Degradation/Loss in Eyes With Geographic Atrophy.

Ophthalmology·2026
Same journal

Access to Intravitreal Anti-VEGF Drugs in Persons with Medicare Advantage Compared with Medicare Fee-For-Service.

Ophthalmology·2026
Same journal

Re: Dones et al.: Emergency department use of ocular point-of-care ultrasound and its utility in diagnosis at a tertiary academic medical center (Ophthalmology. 2026;133:720-727).

Ophthalmology·2026
Same journal

Cataract Surgery and the Risk of Conversion from Dry to Neovascular Age-related Macular Degeneration in the IRIS© Registry.

Ophthalmology·2026
Same journal

Blunt Ocular Trauma from BB Gun Pellet: Long-Term Corneal Endothelial Changes.

Ophthalmology·2026
Same journal

Atypical Sebaceous Adenoma of the Caruncle.

Ophthalmology·2026
See all related articles

Schnyder's crystalline dystrophy, a corneal condition, may progress significantly over time. This challenges the traditional view of this cholesterol deposition disorder as nonprogressive after childhood.

Area of Science:

  • Ophthalmology
  • Genetics
  • Corneal Diseases

Background:

  • Schnyder's crystalline dystrophy involves bilateral central anterior corneal deposits of cholesterol and lipids.
  • Traditionally considered nonprogressive after childhood, recent studies question this long-held belief.

Purpose of the Study:

  • To investigate the long-term progression of Schnyder's crystalline dystrophy.
  • To challenge the established understanding of the condition's nonprogressive nature.

Main Methods:

  • A family pedigree was analyzed, including a patient first reported in 1954 and followed for 25 years.
  • Corneal biopsies underwent light and electron microscopy for pathological examination.
  • Visual acuity was monitored over the follow-up period.

Related Experiment Videos

Main Results:

  • The study patient exhibited dramatic progression of corneal crystal deposition in a dense, discoid pattern.
  • Best-corrected visual acuity decreased from 20/30 to 20/80 in both eyes.
  • Ocular pathology confirmed cholesterol deposition consistent with Schnyder's crystalline dystrophy.

Conclusions:

  • Schnyder's crystalline dystrophy can exhibit significant progression over a patient's lifetime.
  • The classification of Schnyder's crystalline dystrophy as a stationary condition requires reevaluation.