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MR imaging and spectroscopy for prognostic evaluation in soft-tissue sarcomas
H D Sostman1, D M Prescott, M W Dewhirst
1Department of Radiology, Duke University Medical Center, Durham, NC 27710.
Radiology
|January 1, 1994
Summary
Magnetic resonance (MR) imaging and spectroscopy can predict soft-tissue sarcoma treatment response. Pretherapy pH and T2 values correlate with tumor necrosis in humans and relapse-free survival in dogs, aiding prognosis.
Area of Science:
- Oncology
- Radiology
- Biophysics
Background:
- Soft-tissue sarcomas require accurate prognostic indicators for effective treatment planning.
- Magnetic resonance (MR) techniques offer non-invasive methods for assessing tumor characteristics.
Purpose of the Study:
- To evaluate the predictive value of hydrogen-1 T2 and phosphorus-31 MR spectroscopic metabolic determinations for soft-tissue sarcoma prognosis.
- To correlate pretherapy MR parameters with treatment outcomes in humans and canines.
Main Methods:
- Studied 20 humans and 10 dogs with soft-tissue sarcomas undergoing radiation therapy and hyperthermia.
- Assessed pretherapy hydrogen-1 T2 and phosphorus-31 MR spectroscopic parameters.
- Correlated MR data with histologic findings in humans and local relapse-free survival in dogs.
Main Results:
- A significant relationship was found between pretherapy pH and T2 values and ultimate tumor necrosis in humans.
- Pretherapy pH demonstrated a correlation with the time to local failure in dogs.
Conclusions:
- MR imaging and spectroscopy show potential as valuable prognostic tools for soft-tissue sarcomas.
- These non-invasive methods can aid in predicting treatment response prior to initiating therapy.