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[Transitory monoclonal gammaopathy after smallpox vaccination]

G Cohnen, H P Brouwers, G Brittinger

    Schweizerische Medizinische Wochenschrift
    |June 19, 1976
    PubMed
    Summary

    A woman developed transient monoclonal gammopathy of immunoglobulin kappa-type after smallpox vaccination. This immunoglobulin abnormality resolved spontaneously within 10 months.

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    Area of Science:

    • Immunology
    • Vaccinology

    Background:

    • Monoclonal gammopathy is an immunoglobulin abnormality.
    • It can be associated with various disorders, including infectious and inflammatory processes.

    Observation:

    • A 51-year-old female developed monoclonal gammopathy of immunoglobulin kappa-type (IgMk).
    • This condition emerged following smallpox vaccination.

    Findings:

    • The M-component was detectable for 10 months, with decreasing concentrations.
    • The immunoglobulin abnormality resolved spontaneously.

    Implications:

    • This case highlights a potential link between vaccination and transient monoclonal gammopathy.
    • It contributes to the understanding of immunoglobulin abnormalities and their transient nature.

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