Related Experiment Videos
[Guillain-Barré syndrome in children treated with intravenous immunoglobulin]
1Paediatrisk afdeling, Randers Centralsygehus.
The clinical course of subacute demyelinating polyneuropathy or Guillain-Barré syndrome (GBS) in adults is known to improve more rapidly and with fewer complications when treated with plasma exchange or intravenous immunoglobulin than supportive care alone. Recent results indicate the best improvement is found with intravenous immunoglobulin. In children little is known about the efficacy of intravenous immunoglobulin, though case reports seem to document effect. Three cases of GBS in children aged two, three and nine years, who all were treated with intravenous immunoglobulin 400 mg/kg/day for five days, are reported. There was marked clinical improvement during treatment in two children, the third child developed respiratory insufficiency needing artificial respiration during treatment, but improved rapidly after five days of intravenous immunoglobulin.
The clinical course of subacute demyelinating polyneuropathy or Guillain-Barré syndrome (GBS) in adults is known to improve more rapidly and with fewer complications when treated with plasma exchange or intravenous immunoglobulin than supportive care alone. Recent results indicate the best improvement is found with intravenous immunoglobulin. In children little is known about the efficacy of intravenous immunoglobulin, though case reports seem to document effect. Three cases of GBS in children aged two, three and nine years, who all were treated with intravenous immunoglobulin 400 mg/kg/day for five days, are reported. There was marked clinical improvement during treatment in two children, the third child developed respiratory insufficiency needing artificial respiration during treatment, but improved rapidly after five days of intravenous immunoglobulin.