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Continuous nebulised salbutamol and oral once a day prednisolone in status asthmaticus

M Singh1, L Kumar

  • 1Department of Paediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Archives of Disease in Childhood
|October 1, 1993
PubMed

Insights

Continuous nebulised salbutamol and oral prednisolone offer a safe and effective treatment for pediatric status asthmaticus. This approach led to faster clinical improvement and shorter hospital stays compared to conventional methods.

Area of Science:

  • Pediatric Pulmonology
  • Emergency Medicine

Background:

  • Status asthmaticus in children is a severe respiratory condition requiring effective treatment.
  • Conventional protocols often involve intravenous medications with potential side effects and longer hospitalizations.

Purpose of the Study:

  • To evaluate the efficacy and safety of continuous nebulised salbutamol and daily oral prednisolone in pediatric status asthmaticus.
  • To compare this novel treatment with a conventional protocol.

Main Methods:

  • A controlled trial involving 11 children with status asthmaticus (Group A) receiving continuous nebulised salbutamol and oral prednisolone.
  • Comparison with a matched control group (Group B) receiving aminophylline infusion and intravenous hydrocortisone.

Main Results:

  • Group A showed earlier improvements in clinical asthma scores, oxygen saturation (SaO2), and peak expiratory flow rate (PEFR).
  • Significantly higher mean SaO2 and PEFR values were observed in Group A.
  • 9 out of 11 patients in Group A were discharged within 24 hours, versus 3 out of 11 in Group B.

Conclusions:

  • Continuous nebulised salbutamol with daily oral prednisolone is a safe and effective treatment for pediatric status asthmaticus.
  • This regimen facilitates quicker recovery and reduces hospital length of stay.

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