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Possible interaction between phenobarbital, carbamazepine and itraconazole
M Bonay1, A P Jonville-Bera, P Diot
1Service de Pneumologie, CHU Bretonneau, Tours, France.
Drug Safety
|October 1, 1993
Summary
This case study suggests phenobarbital and carbamazepine may reduce itraconazole levels by inducing liver enzymes. Further research is needed to confirm this drug interaction and its clinical significance.
Area of Science:
- Pharmacology
- Clinical Pharmacy
- Drug Interactions
Background:
- Itraconazole is an antifungal medication.
- Phenobarbital and carbamazepine are commonly used drugs with known enzyme-inducing properties.