Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Paraquat causes chronic ocular surface toxicity

K Vlahos1, M Goggin, D Coster

  • 1Flinders Medical Centre, Bedford Park, South Australia.

Australian and New Zealand Journal of Ophthalmology
|August 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acute kidney injury during treatment for latent tuberculous infection with rifampin.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2017
Same author

Performance of distributed multiscale simulations.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences·2014
Same author

Newer emerging pathogens of ocular non-sporulating molds (NSM) identified by polymerase chain reaction (PCR)-based DNA sequencing technique targeting internal transcribed spacer (ITS) region.

Current eye research·2008
Same author

Late onset post-keratoplasty astigmatism in patients with keratoconus.

The British journal of ophthalmology·2004
Same author

I'm behind you! The manager as a coach.

Nursing economic$·2000
Same author

Management of irregular astigmatism.

Current opinion in ophthalmology·2000

Topical paraquat exposure caused severe eye damage due to herbicide absorption and redox cycling. This case highlights ocular paraquat toxicity from direct contact.

Area of Science:

  • Ophthalmology
  • Toxicology
  • Environmental Health

Background:

  • Paraquat is a widely used herbicide with known systemic toxicity.
  • Ocular exposure to paraquat can occur through direct contact with contaminated solutions.
  • The formulation of paraquat solutions may influence ocular absorption and toxicity.

Observation:

  • A case of chronic, severe ocular surface destruction following topical exposure to a commercial paraquat solution is presented.
  • The ocular damage was characterized by significant destruction of the eye's surface tissues.
  • The severity of the damage suggests substantial absorption of the herbicide into ocular tissues.

Findings:

  • Herbicide absorption into ocular surface tissues was a primary factor in the observed toxicity.

Related Experiment Videos

  • A surfactant in the paraquat preparation likely facilitated increased absorption.
  • Intracellular redox cycling of the paraquat cation contributed to cellular damage and toxicity.
  • Ocular paraquat toxicity mechanisms are comparable to those of systemic paraquat poisoning.

    • Implications:

    • This case underscores the severe risks associated with topical paraquat exposure to the eyes.
    • Understanding the role of surfactants is crucial for managing paraquat-related eye injuries.
    • Preventive measures and prompt treatment are essential to mitigate ocular paraquat toxicity.
    • Further research into ocular paraquat toxicity can inform safety guidelines and clinical management.