[Glycogen and enzymes involved in its biosynthesis in rat liver during liver carcinogenesis caused by...

An attempt was made to correlate variations in the level of glycogen during chemically induced carcinogenesis (DENA) with changes in the activity of enzymes participating in biosynthesis of this polysaccharide (UDPG-glycosensynthetase, phosphoglucomutase, UDPG-pyrophosphorylase). It is found that in DENA action in the rat liver two phases may be sharply differentiated--initial (the 1st month) with marked alterations in the content of glycogen and the activity of related enzymes, and final one (4-6th month) which is characterized by reduction of glycogen content, a new sharp rise in the activity of phosphoglucomutase and UDPG-pyrophosphorylase, and somewhat decreased activity of UDPG-glycogensynthetase, as compared with the initial values.