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Plasma carnitines: reference values in an ambulatory population

O Boulat1, B Janin, P Francioli

  • 1Laboratoire Central de Chimie Clinique, Centre Hospitalier Universitaire Vaudois, Lausanne, Suisse.

European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies
|September 1, 1993
PubMed
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Plasma carnitine levels vary significantly between sexes and with age. Researchers recommend matching sex and age in studies investigating carnitine concentrations to ensure accurate results.

Area of Science:

  • Biochemistry and Clinical Chemistry
  • Nutritional Science
  • Cardiovascular Risk Assessment

Background:

  • Carnitine plays a crucial role in energy metabolism, particularly fatty acid oxidation.
  • Understanding carnitine plasma concentrations is vital for assessing metabolic health and cardiovascular risk.
  • Previous studies have not fully elucidated the influence of demographic factors on carnitine levels.

Purpose of the Study:

  • To determine plasma carnitine concentrations (total, free, and acyl) in a large cohort.
  • To investigate the impact of sex, age, and body mass index on carnitine levels.
  • To establish reference ranges for carnitine in a healthy adult population.

Main Methods:

  • Radioenzymatic assay used to quantify plasma carnitine levels.

Related Experiment Videos

  • Analysis performed on 415 hospital employees, with a reference population (N=340) selected.
  • Exclusion criteria included hypertension, diabetes mellitus, and hypercholesterolemia treatment.

    • Main Results:

    • Females exhibited lower total and free carnitine but a higher acyl/free ratio compared to males.
    • Age influenced carnitine levels, with differences diminishing in older individuals (≥35-45 years).
    • Elevated body mass index (>28) in females was associated with a lower acyl/free ratio.

    Conclusions:

    • Plasma carnitine concentrations are significantly influenced by sex and age.
    • The acyl/free carnitine ratio is a sensitive indicator affected by sex and BMI.
    • Sex and age matching is essential for patient and experimental groups in carnitine studies.