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Related Experiment Videos

Tolerance of antacids

K F Sewing1

  • 1Department of General Pharmacology, Medical School, Hannover, Germany.

Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society
|September 1, 1993
PubMed
Summary

Aluminium-containing antacids are generally safe for individuals with normal kidney function. While excessive aluminium can cause harm, typical antacid use leads to safe plasma levels.

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Area of Science:

  • Pharmacology and Toxicology
  • Gastroenterology

Background:

  • Aluminium-containing antacids are widely used for managing acid reflux and indigestion.
  • Concerns exist regarding potential aluminium toxicity, including neurological effects and bone disease (osteomalacia).

Purpose of the Study:

  • To evaluate the safety of aluminium-containing antacids concerning potential toxicity in individuals with normal renal function.

Main Methods:

  • The study assessed the absorption and plasma levels of aluminium following ingestion of aluminium-containing antacids.
  • Focus was placed on individuals with intact kidney function.

Main Results:

  • Ingested aluminium from antacids is minimally absorbed from the gastrointestinal tract.
  • Plasma aluminium levels show only a transient increase, remaining well below toxic concentrations.

Conclusions:

  • Aluminium-containing antacids are considered safe for individuals with normal renal function.
  • The transient increase in plasma aluminium does not reach levels associated with toxicity.

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