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Related Experiment Videos

Neuronal birth and death

E Gould1, B S McEwen

  • 1Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021.

Current Opinion in Neurobiology
|October 1, 1993
PubMed
Summary
This summary is machine-generated.

Postnatal neurogenesis and cell death in the rat dentate gyrus are regulated by adrenal steroids, potentially involving excitatory amino acids and specific genes. These factors influence the development and maintenance of this crucial brain region.

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Area of Science:

  • Neuroscience
  • Cell Biology
  • Developmental Biology

Background:

  • Neurogenesis and cell death are prominent in the postnatal rat dentate gyrus.
  • Adrenal steroids are implicated in regulating mitosis and apoptosis in this region.
  • Excitatory amino acids may mediate steroid effects on cell proliferation and death.

Purpose of the Study:

  • To investigate the regulatory mechanisms of neurogenesis and cell death in the postnatal dentate gyrus.
  • To explore the role of adrenal steroids and excitatory amino acids in these processes.
  • To identify potential genes involved in dentate gyrus development and maintenance.

Main Methods:

  • Studies on postnatal rat dentate gyrus.
  • Analysis of mitosis and apoptosis.

Related Experiment Videos

  • Investigation of adrenal steroid and excitatory amino acid regulation.
  • Examination of genes mediating cell birth and death.

    • Main Results:

    • Mitosis and apoptosis in the dentate gyrus are regulated by adrenal steroids.
    • Excitatory amino acids may play a role in this regulation.
    • Genes involved in cell birth and death might be crucial for dentate gyrus development.

    Conclusions:

    • Adrenal steroids are key regulators of postnatal dentate gyrus development.
    • Further research into specific genes is warranted for understanding dentate gyrus maintenance.
    • The interplay between steroids, amino acids, and gene expression is critical for hippocampal development.