Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

209
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
209
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

181
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
181
Cardiopulmonary Resuscitation IV: Pharmacological Management01:25

Cardiopulmonary Resuscitation IV: Pharmacological Management

536
Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...
536
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

533
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
533
Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

652
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
652
Inhalational Anesthetics: Overview01:20

Inhalational Anesthetics: Overview

925
Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...
925

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PET and SPECT imaging of a radiolabeled minigastrin analogue conjugated with DOTA, NOTA, and NODAGA and labeled with (64)Cu, (68)Ga, and (111)In.

Molecular pharmaceutics·2014
Same author

Resistance to the tyrosine kinase inhibitor axitinib is associated with increased glucose metabolism in pancreatic adenocarcinoma.

Cell death & disease·2014
Same author

Computer-assisted Self Assessment.

Medical teacher·2014
Same author

Molecular imaging of inflammation/infection: nuclear medicine and optical imaging agents and methods.

Chemical reviews·2010
Same author

Bifunctional bisphosphonate complexes for the diagnosis and therapy of bone metastases.

Chemical communications (Cambridge, England)·2009
Same author

99mTc-interleukin-2 scintigraphy in normal subjects and in patients with autoimmune thyroid diseases: a feasibility study.

European journal of nuclear medicine and molecular imaging·2008
Same journal

The autopsy in the 1990s.

British journal of hospital medicine·1999
Same journal

Screening for breast cancer.

British journal of hospital medicine·1999
Same journal

Cost-effective monotherapy of concomitant benign prostatic hyperplasia and hypertension.

British journal of hospital medicine·1999
Same journal

Liposarcoma: a review of current diagnosis and management.

British journal of hospital medicine·1999
Same journal

How to do it in surgery: laparoscopic rectopexy.

British journal of hospital medicine·1999
Same journal

The management of ovarian cancer.

British journal of hospital medicine·1999
See all related articles

Related Experiment Video

Updated: Jan 5, 2026

Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model
04:55

Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model

Published on: May 26, 2023

1.3K

Paediatric anaesthetic emergencies

S J Mather1

  • 1Royal Hospital for Sick Children, Bristol.

British Journal of Hospital Medicine
|October 6, 1993
PubMed
Summary
This summary is machine-generated.

Adequate resuscitation makes anesthesia safe for even critically ill neonates. Most pediatric surgical emergencies can be delayed for a few hours for optimal treatment in a hospital setting.

More Related Videos

Anesthesia and Intubation of Preadolescent Mouse Pups for Cardiothoracic Surgery
09:47

Anesthesia and Intubation of Preadolescent Mouse Pups for Cardiothoracic Surgery

Published on: June 2, 2022

2.7K
Guidelines for Elective Pediatric Fiberoptic Intubation
11:19

Guidelines for Elective Pediatric Fiberoptic Intubation

Published on: January 17, 2011

18.3K

Related Experiment Videos

Last Updated: Jan 5, 2026

Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model
04:55

Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model

Published on: May 26, 2023

1.3K
Anesthesia and Intubation of Preadolescent Mouse Pups for Cardiothoracic Surgery
09:47

Anesthesia and Intubation of Preadolescent Mouse Pups for Cardiothoracic Surgery

Published on: June 2, 2022

2.7K
Guidelines for Elective Pediatric Fiberoptic Intubation
11:19

Guidelines for Elective Pediatric Fiberoptic Intubation

Published on: January 17, 2011

18.3K

Area of Science:

  • Pediatric Anesthesiology
  • Neonatal Surgery

Background:

  • Contraindications for anesthesia in neonates are minimal with proper resuscitation.
  • Most pediatric surgical emergencies do not require immediate intervention.

Purpose of the Study:

  • To highlight the safety and feasibility of anesthesia in sick neonates.
  • To discuss the timing of interventions for pediatric surgical emergencies.

Main Methods:

  • Review of anesthetic management protocols for neonates.
  • Analysis of pediatric surgical emergency case data.

Main Results:

  • Anesthesia is virtually contraindicated in few cases for neonates post-resuscitation.
  • Severe trauma and airway issues are primary reasons for immediate pediatric surgical intervention.

Conclusions:

  • Anesthesia is safe for neonates when adequate resuscitation is performed.
  • Most pediatric surgical emergencies can be managed electively within hours, optimizing hospital resource utilization.