Related Experiment Videos
Midazolam sedation for percutaneous liver biopsy
1Department of Medicine, Burns Clinic Medical Center, Petoskey, Michigan 49770.
Digestive Diseases and Sciences
|December 1, 1993
Summary
Intravenous midazolam is safe for percutaneous liver biopsy (PLB) and reduces patient memory of the procedure. Sedation did not increase complication risks during PLB.
Area of Science:
- Hepatology
- Anesthesiology
- Gastroenterology
Background:
- Percutaneous liver biopsy (PLB) requires controlled respiration, which can be compromised by sedation.
- Evaluating the impact of sedation on PLB safety and patient experience is crucial.
Purpose of the Study:
- To assess the safety of PLB when administered with intravenous midazolam.
- To evaluate patient acceptance of PLB, comparing sedated versus non-sedated procedures.
Main Methods:
- A study involving 301 percutaneous liver biopsies in 217 patients.
- 151 biopsies were performed under intravenous midazolam sedation.
- Patient-reported outcomes including discomfort, memory, and willingness for repeat biopsy were assessed in 61 patients.
Main Results:
- Major complication rates were identical (0.7%) in both sedated and non-sedated groups.
- Sedated patients reported significantly lower procedural memory scores (P < 0.01).
- Mean pain scores were numerically lower in sedated patients (P = 0.07), with similar willingness for repeat procedures.
Conclusions:
- Intravenous midazolam does not increase the risk of complications during percutaneous liver biopsy.
- Midazolam sedation significantly reduces patient recall of the liver biopsy procedure.