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Related Experiment Videos

Clinical trials using ascorbic acid aerosol to aid smoking cessation

E D Levin1, F Behm, E Carnahan

  • 1Department of Psychiatry, Duke University Medical Center, Durham, NC.

Drug and Alcohol Dependence
|October 1, 1993
PubMed
Summary

Ascorbic acid aerosol delivered via a cigarette substitute aided smoking cessation and reduced cravings. While initial abstinence rates were higher, long-term effects required further investigation, suggesting potential benefits for quitting smoking.

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Area of Science:

  • Nicotine Addiction and Smoking Cessation Research
  • Respiratory Medicine
  • Pharmacology

Background:

  • Sensory cues from cigarette smoke are crucial for smoking satisfaction.
  • Previous research indicates citric acid aerosol can reduce cigarette cravings and aid cessation.
  • Ascorbic acid (vitamin C) aerosol was investigated as a novel sensory substitute for smoking cessation.

Purpose of the Study:

  • To evaluate the effectiveness of an ascorbic acid aerosol as a smoking substitute in two clinical trials.
  • To determine if ascorbic acid aerosol can reduce cigarette cravings and improve smoking reduction and abstinence.
  • To investigate the role of tracheobronchial sensations in craving relief using different particle sizes of ascorbic acid.

Main Methods:

  • Two clinical trials were conducted using a cigarette-sized device delivering ascorbic acid aerosol (approx. 1 mg/puff, max 300 mg/day).

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  • Study 1 compared the ascorbic acid device plus counseling versus counseling alone for smoking cessation.
  • Study 2 compared fine vs. coarse particle ascorbic acid aerosols to assess the impact of tracheobronchial sensation on craving.

    • Main Results:

    • Study 1 showed significantly higher abstinence rates at 3 weeks for the group using the ascorbic acid device, though differences diminished post-cessation.
    • Study 2 found initial smoking reduction with fine particle aerosol, but similar reduction by 5 weeks for both groups.
    • Fine particle aerosol use was associated with significantly lower cigarette craving, negative mood, and hunger in abstinent participants.

    Conclusions:

    • Ascorbic acid aerosol delivered via a cigarette substitute shows promise for reducing smoking and aiding cessation.
    • Tracheobronchial sensations, potentially mediated by fine particle aerosols, may play a role in reducing craving and negative mood during smoking cessation.
    • Further research is warranted to optimize delivery and assess long-term efficacy of ascorbic acid as a smoking cessation aid.