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[Sensitivity of gonnococci to penicillin in various forms of gonorrhea 1958-1974]
Abstract:
The dynamics of the changes in sensitivity of gonococci to penicillin within 1958-1974 was studied. It was shown that penicillin sensitivity of gonococci decreased. The sensitivty of gonococci was transferred on passages which explains predominant isolation of the resistant strains from males with fresh gonorrhea and from females with chronic gonorrhea and girls. Gonococci with low sensitivity levels to penicillin were isolated from most of the patients with complicated and ascending forms of gonorrhea. The resistance development was often preceded by irrational and incompleted therapy.
Insights
Penicillin resistance in gonococci increased significantly between 1958 and 1974. This decreased sensitivity was linked to incomplete antibiotic therapy and observed more in complicated gonorrhea cases.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Neisseria gonorrhoeae (gonococci) infections pose a significant public health challenge.
- Penicillin was a primary treatment for gonorrhea, but resistance has emerged over time.
Purpose of the Study:
- To investigate the temporal trends in gonococcal penicillin sensitivity from 1958 to 1974.
- To identify factors associated with the development and spread of penicillin resistance in gonococci.
Main Methods:
- Retrospective analysis of gonococcal isolates collected between 1958 and 1974.
- Assessment of penicillin sensitivity levels in bacterial strains.
- Correlation of resistance patterns with patient demographics and clinical presentation.
Main Results:
- A clear decrease in gonococcal sensitivity to penicillin was observed during the study period.
- Penicillin resistance was transferable between gonococcal strains.
- Resistant strains were predominantly isolated from males with acute gonorrhea, females with chronic gonorrhea, and girls.
- Lower penicillin sensitivity correlated with complicated and ascending gonorrhea forms.
- Incomplete or irrational antibiotic therapy frequently preceded resistance development.
Conclusions:
- Penicillin resistance in gonococci significantly increased between 1958 and 1974.
- Therapeutic practices, including incomplete treatment, played a role in the rise of resistance.
- Understanding resistance dynamics is crucial for effective gonorrhea treatment strategies.