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Maternal effect and familial aggregation in NIDDM. The CODIAB Study. CODIAB-INSERM-ZENECA Study Group
F Thomas1, B Balkau, F Vauzelle-Kervroedan
1Unité de Recherches Cliniques et Epidémiologiques, Institut National de la Santé et de la Recherche Médicale (INSERM U21), Villejuif, France.
Diabetes
|January 1, 1994
Summary
Non-insulin-dependent diabetes mellitus (NIDDM) shows strong familial aggregation, with mothers playing a significant role. This suggests a genetic component influenced by maternal factors in NIDDM inheritance.
Area of Science:
- Endocrinology
- Genetics
- Epidemiology
Background:
- Non-insulin-dependent diabetes mellitus (NIDDM) has a known genetic basis, but its inheritance pattern remains unclear.
- Recent research suggests maternal inheritance may play a crucial role, complicating NIDDM transmission patterns.
Purpose of the Study:
- To investigate the familial aggregation of diabetes.
- To examine the potential maternal effect on NIDDM inheritance across three generations.
Main Methods:
- The CODIAB Study recruited 536 NIDDM patients aged 35-74 from 10 French diabetes centers.
- Data analysis focused on familial aggregation and maternal vs. paternal influence on diabetes transmission.
Main Results:
- Familial aggregation of NIDDM was confirmed, with 66% of patients having a diabetic relative.
- Mothers were implicated twice as frequently as fathers (P < 0.001).
- A significant maternal effect was observed, with more diabetic cases among maternal relatives and offspring of women.
Conclusions:
- NIDDM exhibits strong familial aggregation, indicating a significant genetic component.
- A maternal effect, potentially environmental, influences the mode of NIDDM inheritance.
- Further research is needed to elucidate the precise mechanisms of NIDDM inheritance.