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Long-term exposure to SMS 201-995 inhibits proliferation and calcitonin release in neoplastic C-cells
1Department of Biology, Faculty of Science, Addis Abeba University, Ethiopia.
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|October 1, 1993
Abstract:
The effect of the long-acting somatostatin analogue SMS 201-995 on cellular proliferation and calcitonin production was examined in rMTC 6-23 cells. A dose-dependent inhibition of calcitonin release and cellular calcitonin content was obtained in cells exposed to SMS 201-995 for 72 hrs. The dose-dependent antiproliferative effect of SMS 201-995 (10(-8)-10(-6) M) was significant after 72 hrs of exposure. SMS 201-995 has an inhibitory effect on calcitonin secretion and synthesis as well as on the growth of C-cells.