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Treatment of Candida arthritis with flucytosine and amphotericin B

M E Weisse1, D A Person, J T Berkenbaugh

  • 1Department of Pediatrics, Tripler Army Medical Center, Honolulu, Hawaii.

Journal of Perinatology : Official Journal of the California Perinatal Association
|September 1, 1993
PubMed

Insights

A premature infant with disseminated Candida tropicalis infection showed persistent joint infection despite amphotericin B treatment. Adding oral flucytosine (5-fluorocytosine) successfully cleared the yeast from synovial fluid, demonstrating its efficacy in invasive Candida arthritis.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Pediatric Rheumatology

Background:

  • Disseminated Candida tropicalis infection in premature infants can lead to severe joint involvement, including arthritis and osteomyelitis.
  • Standard antifungal therapy with amphotericin B may not always achieve rapid fungal clearance from synovial fluid.

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