Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Plasma endothelin level changes during hemorrhagic shock

H Chang¹, G J Wu, S M Wang

¹Department of Emergency Medicine, Shih Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan, Republic of China.

The Journal of Trauma

|December 1, 1993

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[A single-center analysis of pathogenic bacteria distribution and drug resistance in bacterial bloodstream infections among patients with hematological diseases].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi·2024

Same author

[Differential analysis of aqueous humor metabolomics between presenile cataract and senile cataract].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology·2024

Same author

[The safety and efficacy of prophylactic hyperthermic intraperitoneal chemotherapy for elderly patients with locally advanced gastric cancer: a propensity score matching analysis].

Zhonghua yi xue za zhi·2023

Same author

[Analysis of prognosis and related factors in oldest-old patients with left-side or right-side colon cancer after hemicolectomy].

Zhonghua yi xue za zhi·2023

Same author

[A descriptive analysis of tea consumption in adult twins in China].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2022

Same author

[A descriptive analysis on type 2 diabetes in twins in China].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2022

Plasma endothelin-1 levels increase during hemorrhagic shock, correlating with blood loss. This study analyzed endothelin-1 changes in dogs experiencing controlled hypotension to understand its role in shock.

Area of Science:

Physiology
Cardiovascular Research
Hemodynamics

Background:

Endothelin-1 is a potent vasoconstrictor.
Its role in hemorrhagic shock requires further elucidation.

Purpose of the Study:

To analyze changes in plasma endothelin-1 levels during hemorrhagic shock in a canine model.

Main Methods:

Thirty-two dogs were subjected to controlled hemorrhagic shock at varying mean arterial pressures (65, 50, 40 mm Hg).
Plasma endothelin-1 levels were measured in arterial and venous blood at multiple time points before and after shock induction.
Arterial/venous ratios were calculated.

Main Results:

Baseline arterial endothelin-1 was lower than venous levels.

Related Experiment Videos

Plasma endothelin-1 concentrations increased significantly after shock onset.

Elevated endothelin-1 levels showed a linear correlation with the extent of blood loss from 2 hours post-shock onwards.

The arterial/venous ratio of endothelin-1 increased during oligemic periods compared to controls.

Conclusions:

Hemorrhagic shock induces a marked increase in plasma endothelin-1.
Endothelin-1 levels are directly related to the severity and duration of blood loss.
Increased endothelin-1 may play a role in the pathophysiology of hemorrhagic shock.