Enhancement of the antitrichomonal activity of 5-nitroimidazole derivatives by hydrogen peroxide
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A Mattana1, C Juliano, V Picci
1Istituto di Chimica Biologica, Facoltà di Farmacia, Università di Sassari, Italy.
The New Microbiologica
|October 1, 1993
Abstract:
The in vitro sensitivity of nine Trichomonas vaginalis isolates to commonly employed 5-nitroimidazoles (metronidazole, nimorazole, ornidazole and tinidazole) was evaluated in absence and in presence of sub-inhibitory concentrations of hydrogen peroxide (H2O2). Co-incubation with H2O2 and 5-nitroimidazole compounds decreased the MIC values of the strains exhibiting cross-resistance to these drugs. It was suggested that H2O2 produced in the inflammatory process during trichomonal infection could enhance the therapeutic effect of 5-nitroimidazole drugs.